Released in 2011, The Binding of Isaac is a randomly generated action RPG shooter with heavy rogue-like elements. You guide Isaac through a monster-filled basement, battling creatures and collecting bizarre treasures that permanently alter his form and abilities for that run. The core loop involves descending through procedurally generated floors, where item synergies create highly variable gameplay experiences. The dark story is loosely inspired by the biblical tale, featuring multiple endings based on player progression.

The Binding of Isaac: Rebirth is a top down, procedurally-generated roguelike game, remade based on the original game The Binding of Isaac. You play as Isaac, a little boy who is chased to the basement by his mother who intends to kill Isaac for her savior. You explore different levels, collect items and try to defeat your mother.. and whatever other evil awaits you. If you die, you restart with none of your items you collected, and you must explore the basement and beyond again.

The Binding of Isaac: Wrath of the Lamb is an official DLC expansion to The Binding of Isaac, which adds new Items, Rooms, Enemies, Bosses, and more.