《The Binding of Isaac》是一款於 2011 年發行的隨機生成動作 RPG 射擊遊戲,核心為 Roguelike 元素。玩家扮演逃入地下室的男孩以撒,在地牢中探索、戰鬥並面對死亡。遊戲特色在於收集數百種道具,這些道具會不斷疊加並奇特地改變以撒的外觀與能力,使每次闖關體驗都獨一無二。劇情基於聖經故事改編,氣氛黑暗且充滿宗教意象,遊戲提供多重結局。此遊戲擁有官方擴充內容,且已有重製版本問世,提供極高的重玩價值。
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The Binding of Isaac: Rebirth is a top down, procedurally-generated roguelike game, remade based on the original game The Binding of Isaac. You play as Isaac, a little boy who is chased to the basement by his mother who intends to kill Isaac for her savior. You explore different levels, collect items and try to defeat your mother.. and whatever other evil awaits you. If you die, you restart with none of your items you collected, and you must explore the basement and beyond again.

The Binding of Isaac: Wrath of the Lamb is an official DLC expansion to The Binding of Isaac, which adds new Items, Rooms, Enemies, Bosses, and more.