2007年公開の本作は、映画『TMNT』を基にしたアクションアドベンチャーゲームです。プレイヤーはタートルズ四人となり、ハックアンドスラッシュ形式の戦闘とプラットフォームアクションを駆使して進みます。ストーリーはシュレッダー打倒後、離れ離れになった兄弟たちが抱える家族間の軋轢と、再燃するフット団の脅威を中心に展開します。各タートルズの個性を活かしたバトルと、単独での物語体験が特徴のシングルプレイ作品です。
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TMNT is a beat 'em up video game developed by Ubisoft Montreal and published by Ubisoft for the Game Boy Advance handheld video game console. It is based off the 2007 CGI movie. The game was first released in North America on March 20, 2007, and was later released in Australia on March 22, 2007, and in Europe on March 23, 2007. It was one of the last games published for Game Boy Advance, at a time when the Nintendo DS was already halfway through the most prominent phase of its product life cycle. Another game with the same title was also released on the Xbox 360, Wii, PlayStation 2, GameCube, and PC, and the other handheld game on Nintendo DS, and PlayStation Portable video game consoles, though this version is vastly different from any of the others released, it being a 2.5-D side-scrolling beat-'em-up game involving no three-dimensional game play whatsoever.

TMNT is a single-player action-adventure multi-platform action game starring the Teenage Mutant Ninja Turtles. It is based on the 2007 film of the same name, and was released three days before the actual movie's release for the Xbox 360, Wii, PlayStation 2, and Nintendo GameCube video game consoles, as well as for the PC on March 20, 2007. It follows the basic plot of the 2007 film TMNT, straying from it in very few aspects. The original Xbox and PlayStation 3 versions of the game were canceled.