The Binding of Isaac er et tilfældigt genereret action-RPG shooter med stærke rogue-like elementer, udgivet i 2011. Du styrer Isaac, der flygter ned i en uhyggelig kælder fyldt med monstre for at undslippe sin mor. Kernen i spillet er at udforske procedurelt genererede etager, hvor du samler bizarre genstande, der permanent ændrer Isaacs udseende og evner. Hvert gennemspil er unikt på grund af genstandskombinationerne og den intense, mørke atmosfære inspireret af bibelske temaer.
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The Binding of Isaac: Rebirth is a top down, procedurally-generated roguelike game, remade based on the original game The Binding of Isaac. You play as Isaac, a little boy who is chased to the basement by his mother who intends to kill Isaac for her savior. You explore different levels, collect items and try to defeat your mother.. and whatever other evil awaits you. If you die, you restart with none of your items you collected, and you must explore the basement and beyond again.

The Binding of Isaac: Wrath of the Lamb is an official DLC expansion to The Binding of Isaac, which adds new Items, Rooms, Enemies, Bosses, and more.